Anthony L. Mescher, Ph.D.

Image of Dr. Mescher

Emeritus Professor of Anatomy and Cell Biology

Indiana University School of Medicine – Bloomington

Medical Sciences Program

Jordan Hall 201

Indiana University Bloomington

Bloomington, IN 47405

Phone: (812) 855-4693

Fax: (812) 855-4436

Email: mescher@indiana.edu

RESEARCH INTERESTS

Although retired from full-time teaching and research, Dr. Mescher remains an active participant in the regenerative biology community writing and reviewing articles in the field. The most recent research in the Mescher lab involved the interface between the inflammatory effects of amputation injury and the molecular events leading to epimorphic regeneration of amphibian limbs. Specifically, we studied (1) the nature of genes expressed in the early post-amputation period in regenerating hindlimbs of larval frogs, with particular interest in genes related to inflammation, immunity, and dedifferentiation, (2) differences in expression of such genes between young larvae which regenerate limbs completely and older larvae with defective regeneration, in an attempt to elucidate the ontogenic loss of regenerative capacity, and (3) expression patterns and control of genes with an apparent role in both dedifferentiation and limb patterning. Our publications in these areas are listed below (along with a few resources related to teaching). Dr. Mescher also maintains strong interest in the molecular basis of both the apical epithelial effect and the nerves’ trophic effect on blastema cell proliferation, which are required for epimorphic regeneration but remain incompletely understood. Those with interests in these topics are welcome to contact Dr. Mescher for discussions.

SELECTED RECENT PUBLICATIONS

    AL Mescher, MW King, and AW Neff (2016) Inflammation and immunity in organ regeneration. Devel Comp Immunol (in press)
    AL Mescher (2015) Junqueira’s Basic Histology, 14th edition, McGraw-Hill Medical/Lange education, New York, 560 pages
    AL Mescher, AW Neff, and MW King (2013) Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs. PLoS ONE 8:e80477
    AW King, AW Neff, and AL Mescher (2012) The developing Xenopus limb as a model for studies on the balance between inflammation and regeneration. Anat Rec 295: 1552-1561
    AW Neff, MW King, and AL Mescher (2011) Dedifferentiation and the role of Sall4 in reprogramming and patterning during amphibian limb regeneration. Devel Dynam 240: 979-989
    AL Mescher (2011) Basic Histology Flash Cards. McGraw-Hill/Lange Professional division, New York, 400 pages