L. Jack Windsor, Ph.D.
Professor, Department of Biomedical and Applied Sciences, School of Dentistry
Adjunct Professor, Department of Anatomy and Cell Biology, School of Medicine
Indiana University School of Dentistry
Department of Biomedical and Applied Sciences
1121 W. Michigan Street, Room, DS 271
Indianapolis, IN 46202-5186
Phone: (317) 274-1448
The research focus of the laboratory is on the mechanisms by which extracellular matrix (ECM) is remodeled and/or degraded during normal and pathological conditions. The major players in these processes are the matrix metalloproteinases, which are zinc-dependent proteases that cleave multiple components of the ECM. These proteases are also believed to play major roles during growth and development, as well as during the regeneration process. Some of the laboratory’s efforts have been on understanding how the process of ECM turnover can be regulated to enhance tissue regeneration in the oral cavity such as re-establishment (regeneration) of gingival tissues after periodontal disease, as well as the regulation of pulp stem cells and pulp fibroblasts in regards to the regeneration of tooth structure and possible teeth. In addition, the effects that dental materials and environmental factors (i.e., tobacco) have on the repair/regeneration mechanisms of oral and pulp tissues are being examined.
SELECTED RECENT PUBLICATIONS
Saini, P., Al-Shibani, N., Sun, J., Zhang, W., Song, F., Gregson, K., and Windsor, L. J.: Effects of Calendula officinalis on Human Gingival Fibroblasts, Homeopathy, 101(2): 92-98, 2012.
Sun, J., Song, F., Zhang, W., Sexton, B. E., and Windsor, L. J.: Effects of alendronate on human osteoblast-like MG63 cells and matrix metalloproteinases, Arch Oral Biol., 57(6):728-736, 2012.
Kamal, A., Allam, E., Dehis, M., Zunt, S., and Windsor, L. J.: Assessment of changes to the dental follicle in deep and partially impacted mandibular third molar, The Egyptian Ass. Oral and Maxillofacial Surgeons, 3(1): 30-35, 2012.
Borzangy, S., Labban, N., and Windsor, L. J.: Effects of Provision Acrylic Resins on the Expression of Cytokines/Growth Factors from Epithelial Cells and on Collagen Degradation, J Prosthet. Dent., 110(4):296-302, 2013.
Allam, E., DelaCruz, K., Ghonemima, A., Sun, J., and Windsor, L. J.: Effects of Tobacco on cytokine expression from human endothelial cells, Oral Dis., 19(7):660-5, 2013.
Bottino, M. C., Yassen, G. H., Platt, J. A., Labban, N., Windsor, L. J., and Spolnik, K. J.:A novel three-dimensional scaffold for regenerative endodontics: materials and characterizations, J Tissue Eng Regen Med., Mar 8. doi: 10.1002/term.1712, 2013.
Bottino, M. C., Batarseh, G., Palasuk, J., Windsor, L. J., and Platt, J. A.: Nanaotube-Modified Dentin-Adhesive-Physicochemical and Dentin Bonding Characterizations, Dent Mater., 29(11):1158-65, 2013.
Khaled, M., Al-Shibani, N., Labban, N., Baterseh, G., Song, F., Ruby, J., and Windsor, L. J.: Effects of Resolvin D1 on Cell Survival and Cytokine Expression of Human Gingival Fibroblasts, J Periodontol., 84(12):1838-46, 2013.
Reina, E., Sal-Shibani, N., Allam, E., Gregson, K. S., Kowolik, M., and Windsor, L. J.: The Effects of Plantago major on the Activation of the Neutrophil Respiratory Burst, J. Traditional and Complementary Medicine, 3(4): 2013.
Batarseh, G., Labban, L., Liu, Y., Gregson, K. G., and Windsor, L. J: TEGDMA induction of apoptotic proteins in pulp fibroblasts, Oper. Dent., 39(1):E1-8, 2014.
Bauer, A., Liu, J., Windsor, L. J., Song, F., and Li, B: Collagen-based biomaterials for tissue engineering and regenerative medicine, Soft Material, 2014, DOI. 10.1080/1539445X.2014925474.
S. A. Feitosa, J. Palasuk, K. Kamocki, S. Geraldeli, R. L. Gregory, J. A. Platt, L. J. Windsor and M. C. Bottino, Doxycycline-Encapsulated Nanotube-Modified Dentin Adhesives, Journal of Dental Research, 09/2014; 93(12). DOI: 10.1177/0022034514549997
Yassen, G., Labban, N., Platt, J., and Windsor, L. J.: The Direct cytotoxic effects of medicaments used in endodontic regeneration on human dental pulp cells, Dental Traumatology, 3/2014; DOI: 10.1111/edt.12108
Eman Allam, Mia Recupito, Hend Mohamed, and L. Jack Windsor, In Vitro Effects of Nicotine, Cigarette Smoke Condensate, and Porphyromonas gingivalis on Monocyte Chemoattractant Protein-1 Expression from Cultured Human Gingival Fibroblasts, J Interdiscipl Med Dent Sci 2015, 3: 171; doi: 10.4172/2376-032X.1000171
W Kim-Park, E Allam, J Palasuk, M Kowolik, K K Park, and L J Windsor: Green Tea Catechin Inhibits the Activity and Neutrophil Release of Matrix Metalloproteinase-9, Journal of Traditional and Complementary Medicine, http://dx.doi.org?10.1016/j.jtcme.2015.02.002, 2015.
Kim, K. W., Yassen, G., Ehrlich, Y., Spolnik, K., Platt, J., and Windsor, L. J.: The effects of radicular dentine treated with double antibiotic paste and ethylenediaminetetraacetic acid on the attachment and proliferation of dental pulp stem cells, Dental Traumatology,06/2015; 31(5). DOI: 10.1111/edt.12181
Allam, E., Feitosa, S., Palasuk, J., Bottino, M., and Windsor, L. J.: Chapter: Roles of Matrix Metalloproteinases in Periodontal Diseases and Dental Caries, Matrix Metalloproteinases (MMPs): Classification, Molecular Mechanisms and Roles in Diseases, Nova Science Publishers Inc., 2015