David L. Stocum, Ph.D.
Professor of Biology Emeritus
Senior Fellow, Indiana University Institute for Molecular Biology
Research Scholar, Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Board Member, Senior Academy, IUPUI
Department of Biology, School of Science
Indiana University-Purdue University Indianapolis
723 W. Michigan St.
Indianapolis, IN 46202
Phone: (317) 274-0627
Fax: (3127) 274-2846
My research interests have spanned three areas of developmental and regenerative biology. The first is the cellular and molecular mechanisms that determine how limb structures are patterned by the blastema of regenerating urodele limbs. The second is the comparative proteomic analysis of blastema formation to determine the basis of regenerative competence of urodele limbs vs. regeneration deficiency of anuran limbs, with the aim of devising interventions to eliminate regenerative deficiency. The third is use of the urodele limb as a model to investigate how to regenerate skeletal tissue across critical size defects in long bones. Although the research phase of my career has ended with retirement, I remain engaged in two other interests that I have pursued alongside my research. These are (1) writing articles and books that synthesize and promote the rapidly developing field of regenerative biology and medicine; and (2) writing about the devaluing of undergraduate education in public research universities that results from a focus on research and athletic prestige rankings.
SELECTED RECENT PUBLICATIONS
Rao N, Jhamb D, Milner DJ, Li B, Song F, Wang M, Voss SR, Palakal M, King MW, Saranjami B, Nye HLD, Cameron JA, Stocum DL (2009) Proteomic analysis of blastema formation in regenerating axolotl limbs. BMC Biology 7:83.
Song F, Li B, Stocum DL (2010) Amphibians as research models for regenerative medicine. Organogenesis 6:141-150.
Stocum DL, Cameron JA (2011) Looking proximally and distally: 100 years of limb regeneration and beyond. Dev Dynam 240:943-968.
Jhamb D, Rao N, Milner DJ, Song F, Cameron JA, Stocum DL, Palakal MJ (2011) Network based transcription factor analysis of regenerating axolotl limbs. BMC Bioinformatics12:80.
Feng L, Milner DJ, Xia C, Nye HLD, Redwood P, Cameron JA, Stocum DL, Fang N, Jasiuk I (2011) Long bone critical size defect repair by regeneration in adult Xenopus laevis hindlimbs. Tiss Eng Part A, 17:691-701.
Stocum DL (2012) Regenerative Biology and Medicine, 2nd edition. Elsevier/Academic Press, San Diego, 474 pp.
Stocum DL (2013) Killing Public Higher Education: The Arms Race for Research Prestige. Elsevier/Academic Press, San Diego, 36 pp.
Rao N, Song F, Jhamb D, Wang M, Milner DJ, Price NM, Belecky-Adams TL, Palakal MJ, Cameron JA, Li B, Chen X, Stocum DL (2014) Proteomic analysis of fibroblastema formation in regenerating hind limbs of Xenopus laevis froglets and comparison to axolotl. BMC Dev Biol 14:32.
Stocum DL (2015) Regeneration of the urodele limb. Encyclopedia of Life Sciences (eLS), John Wiley and Sons.
Stocum DL (2015) Regeneration of vertebrate tissues: Model systems. Encyclopedia of Life Sciences (eLS), John Wiley and Sons.
Chen X, Song F, Li J, Jhamb D, Bottino M, Palakal M, Stocum DL (2015) Induction of regeneration across a greater than critical size defect in the axolotl fibula. PLoS One 10(6):e0130819.
Stocum DL (2015) Reflections on scientific literacy, education and worldview. Journal of Civic Literacy, July.