Teresa Mastracci, Ph.D.

Image of Dr. Mastracci

Senior Scientist, Indiana Biosciences Research Institute

Adjunct Assistant Professor of Biochemistry & Molecular Biology, Indiana University School of Medicine

Center for Developmental and Regenerative Biology School of Science

Indiana University-Purdue University Indianapolis

Indiana Biosciences Research Institute

1345 W. 16th St., Suite 300

Indianapolis, IN 46202

Phone: 317-983-3350

Email: tmastracci@indianabiosciences.org

RESEARCH INTERESTS

Work in the lab uses the mouse and zebrafish model systems to determine how cells in the pancreas develop, differentiate, and regenerate. In particular, we are interested in understanding the signals that are required to produce functional pancreatic endocrine (islet) cells, including insulin-producing beta cells and glucagon-producing alpha cells, with the goal of applying this knowledge to the generation of therapeutic treatments for type 1 diabetes. Currently, we are investigating key factors in the polyamine and hypusine biosynthesis pathway for their role in the processes of pancreatic and beta cell development, differentiation, and regeneration.

SELECTED RECENT PUBLICATIONS

    Mastracci TL*, Robertson MA, Mirmira RG, Anderson RM. Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Sci Rep. 2015 Aug 24;5:13269. doi: 10.1038/srep13269. PMID: 26299433
    Mastracci TL, Anderson KR, Papizan J, Sussel L. Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet. 2013 Feb;9(2). Epub 2013 Feb 7. PMCID: PMC3567185
    Mastracci TL, Wilcox C, Panea C, Golden J, May CL, Sussel L. Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11. Epub 2011 Aug 11. PMCID: PMC3192309.
    Mastracci TL, Sussel L. The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Dev Biol. 2012 Sep-Oct;1(5):609-28. Epub 2012 Mar 14. PMID: 23799564. PMC3420142.