Teresa Mastracci, Ph.D.
Senior Scientist, Indiana Biosciences Research Institute
Adjunct Assistant Professor of Biochemistry & Molecular Biology, Indiana University School of Medicine
Center for Developmental and Regenerative Biology School of Science
Indiana University-Purdue University Indianapolis
Indiana Biosciences Research Institute
1345 W. 16th St., Suite 300
Indianapolis, IN 46202
Work in the lab uses the mouse and zebrafish model systems to determine how cells in the pancreas develop, differentiate, and regenerate. In particular, we are interested in understanding the signals that are required to produce functional pancreatic endocrine (islet) cells, including insulin-producing beta cells and glucagon-producing alpha cells, with the goal of applying this knowledge to the generation of therapeutic treatments for type 1 diabetes. Currently, we are investigating key factors in the polyamine and hypusine biosynthesis pathway for their role in the processes of pancreatic and beta cell development, differentiation, and regeneration.
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