Jiliang Li, MD, Ph.D.

Image of Dr. Li

Associate Professor

Department of Biology

School of Science

Indiana University-Purdue University Indianapolis

723 W. Michigan St.

Indianapolis, IN 46202-5132

Phone: (317) 278-1163

Fax: (317) 274-2846

E-mail: jilili@iupui.edu


My research interests are in bone cell biology and bone regeneration. I have studied the mechanisms by which exercise builds bone with the goal of identifying novel drug targets linked to increased bone strength. My research activities include the study of the biological and mechanical aspects of bone using animal models and cell cultures, as well as the study of molecular mechanisms of mechanotransduction, the process of conversion of mechanical signals into biological signals in bone cells. My current research has been focused on the role of two transcription factors, Stat3 and Nrf2, in load-driven osteogenesis. I am also involved in studying pharmaceutical treatments for osteoporosis and bone fracture. In addition, I am planning to study biology of endothelial colony forming cells (ECFCs), one type of endothelial progenitor cells, and its role in bone regeneration.


    Blazek JD, Abeysekera I, Li J, Roper RJ 2015 Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a. Hum Mol Genet in press (PMID: 26206885)
    Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, Brown T, Feng JQ, Ke HZ, Bauman WA, Cardozo CC 2015 Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats. J Bone Miner Res in press. (PIMD: 25974843)
    Chen X, Song F, Jhamb D, Li J, Bottino MC, Palakal MJ, Stocum DL 2015 The Axolotl Fibula as a Model for the Induction of Regeneration across Large Segment Defects in Long Bones of the Extremities. PloS ONE 10(6): e0130819. doi:10.1371/journal.pone.0130819 (PMID: 26098852)
    Sun YX, Li L, Corry K, Zhang P, Yang Y, Himes E, Mihuti CL, Nelson C, Dai G, Li J 2015 Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-deriven bone formation. Bone, 74:1-9. (PMID: 25576674)