Guoli Dai, DVM, Ph.D.
Associate Professor of Biology
Department of Biology
Center for Developmental and Regenerative Biology
School of Science
Indiana University-Purdue University Indianapolis
723 W. Michigan Street
Indianapolis, IN 46204
Phone: (317) 278-3895
Fax: (317) 274-2846
My laboratory investigates the molecular and cellular mechanisms regulating liver growth in both physiological and pathological conditions. The maternal liver adapts to pregnancy by marked growth manifested by liver cell proliferation and liver size increase. We are particularly interested in revealing the roles of placental hormones in mediating maternal hepatic adaptations to pregnancy. The liver exhibits robust regenerative responses to acute or chronic liver injuries to restore the lost liver mass and regain original hepatic structure and function, which is a phenomenon of compensatory growth of injured liver. Timely and/or enhanced liver regeneration leads to recovery from liver injury and survival, whereas delayed and/or inhibited liver regeneration results in liver failure and death. We are studying the regulation of hepatocyte proliferation and liver stem/progenitor cell behaviors during pregnancy and liver regeneration. Our goal is to develop a clinical strategy to rescue injured livers by targeting liver repair.
SELECTED RECENT PUBLICATIONS
J Bustamante, BL Copple, MJ Soares, G Dai. 2010. Gene Profiling of Maternal Hepatic Adaptations to Pregnancy. Liver International, 30(3):406-415.
G Dai, J Bustamante, Y Zou, A Myronovych, Q Bao, S Kumar, and MJ Soares. 2011. Maternal Hepatic Growth Response to Pregnancy in the Mouse. Experimental Biology and Medicine, 236:1322-1332.
Y Zou, Q Bao, S Kumar, M Hu, GY Wang, G Dai. 2012. Four Waves of Hepatocyte Proliferation Linked with Three Waves of Hepatic Fat Accumulation during Partial Hepatectomy-Induced Liver Regeneration. PLoS ONE, 7(2):e30675.
Sudhanshu Kumar, Yuhong Zou, Qi Bao, Mu Wang, and Guoli Dai. 2012. A Proteomic Analysis of Immediate-Early Response Plasma Proteins after 70% and 90% Partial Hepatectomy. Hepatology Research, Nov 27. doi: 10.1111/hepr.12030. (The first and second authors equally contribute).
Yuhong Zou, Min Hu, Qi Bao, Jefferson Y. Chan and Guoli Dai. 2013. Nrf2 Participates in Regulating Maternal Hepatic Adaptations to Pregnancy. Journal of Cell Science, Apr 1;126(Pt 7):1618-25.
BC Yaden, Y Wang, J Croy, A Milner, J Wilson, P Shelter, G Dai, and VK Krishnan. 2013. Inhibition of Activin A Ameliorates Skeletal Muscle Injury and Rescues Contractile Properties in Mice. American Journal of Pathology, Apr;184(4):1152-66.
Benjamin C. Yaden, Johnny E. Croy, Yan Wang, John M. Wilson, Amita Datta-Mannan, Pamela Shetler, Andrea Milner, Jessica Andrews, Henry U. Bryant, Guoli Dai and Venkatesh Krishnan. 2014. Follistatin: A Novel Therapeutic for the Improvement of Muscle Regeneration. Journal of Pharmacology and Experimental Therapeutics, May;349(2):355-71.
Min Hu, Yuhong Zou, Shashank Manohar Nambiar, Joonyong Lee, Yan Yang and Guoli Dai. 2014. Keap1 Modulates the Redox Cycle and Hepatocyte Cell Cycle in Regenerating Liver. Cell Cycle, May 27;13(15).
Yuhong Zou, Joonyong Lee, Shashank Manohar Nambiar, Min Hu, Wenjuan Rui, Qi Bao,
Jefferson Y. Chan and Guoli Dai. 2014. Nrf2 Is Involved in Maintaining Hepatocyte Identity during Liver Regeneration. PLoS ONE, 15;9(9):e107423
Zou Y, Hu M, Lee J, Nambiar SM, Garcia V, Bao Q, Chan JY, Dai G. 2015. Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration. Am J Physiol Gastrointest Liver Physiol. Feb 15;308(4):G262-8.