Anton Neff

Image of Dr. Neff

Professor

Medical Sciences Program

Jordan Hall 201

Indiana University Bloomington

Bloomington, IN 47405

Phone: (812) 821-3096

Fax: (812) 855-4436

Email: neff@indiana.edu

RESEARCH INTERESTS

The Neff lab is interested in the molecular and cellular interactions required for tissue and organ regeneration utilizing amphibian model systems. Current work involves differential genomics and proteomics to identify limb regeneration regulatory pathways with emphasis on immunomodulatory and stem cell establishment/maintenance pathways.

SELECTED RECENT PUBLICATIONS

    Harty, M., A.W. Neff, M.W. King, and A.L. Mescher (2003) Regeneration or scarring: An immunologic perspective. Dev. Dyn 226:268-279
    King, M.W., T. Nguyen, J. Calley, M.W. Harty, M.C. Muzinich, A.L. Mescher, C. Chalfant, M. N’Cho, K. McLeaster, J. McEntire, D. Stocum, R.C. Smith, and A.W. Neff. (2003) Identification of genes expressed during Xenopus laevis limb regeneration by using subtractive hybridization. Dev. Dyn 226:398-409
    Mescher AL, Neff AW (2005). Regenerative capacity and the developing immune system. Adv. Biochemical Engineering/ Biotechnology 93:39-66.
    Neff AW, King MW, Harty MW, Nguyen T, Calley J, Smith RC, Mescher AL. (2005) Expression of Xenopus XlSALL4 during limb development and regeneration. Dev Dyn. 233(2):356-367.
    Grow MW, Neff AW, Mescher AL, King MW. (2006) Global analysis of gene expression in Xenopus limbs during stage-dependent complete and incomplete regeneration. Dev. Dyn. 235:2667-2685.
    AL. Mescher, W L. Wolf, E., A. Moseman, B. Hartman, C. Harrison, E. Nguyen, and AW. Neff (2007) Cells of cutaneous immunity in Xenopus: Studies during larval development. Developmental and Comparative Immunology 31(4):383-93.
    King MW, Neff AW, Mescher AL. (2009) Proteomics analysis of regenerating amphibian limbs: changes during the onset of regeneration. Int J Dev Biol.;53(7):955‐69. doi: 10.1387/ijdb.082719mk
    Neff AW, King MW, Mescher AL. (2011) Dedifferentiation and the role of sall4 in reprogramming and patterning during amphibian limb regeneration. Dev Dyn. May;240(5):979‐89. doi: 10.1002/dvdy.22554. Epub 2011 Feb 8. Review
    King MW, Neff AW, Mescher AL. (2012) The developing Xenopus limb as a model for studies on the balance between inflammation and regeneration. Anat Rec (Hoboken). 2012 Oct;295(10):1552‐61. doi: 10.1002/ar.22443. Epub 2012 Aug 29. Review
    Mescher AL, Neff AW, King MW. (2013) Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs. PLoS One. Nov 20;8(11):e80477. doi: 10.1371/journal.pone.0080477.